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Martin-McGill KJ, Bresnahan R, Levy RG, Cooper PN

APOE4 has also been associated with increased WMH volumes in PD and DLB subjects in some studies, suggesting it may also contribute to white matter abnormalities known to be linked to cognitive impairment in these conditions (Kandel et al., 2016

Coenzyme Qbiosynthesis and functions

isolated means that the material is removed from its original environment (e.g., the natural environment if it is naturally occurring)

By contrast, drugs that target metabolic pathways (e.g., GLUT1 inhibitors, PPP inhibitors, PDK inhibitors, and glutaminase inhibitors) may provide promising efficacy in ovarian cancer cells harboring nutrient addiction

In doing so, they generate reactive oxygen species (ROS) as a by-product (Lee et al., 2010)