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When CIV is predominantly oxidized at normoxic oxygen concentrations, NO binds to the copper center in a manner that does not obstruct concurrent oxygen binding (Pappas et al., 2023

Glutathione exhibits greater stability than cysteine during extraction as a consequence of the higher pKa of its thiol group, which provides some protection against oxidation

Only mix the desired doses in a syringe immediately prior to administration to ensure maximum stability and potency