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Vitamin B12 injections are most clinically appropriate in cases of confirmed vitamin B12 deficiency, malabsorption syndromes including pernicious anaemia or post-gastric surgery, significant symptoms where rapid restoration of vitamin B12 levels is required, or failure of oral supplementation due to poor absorption

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TLRs are expressed across a broad range of cell types, extending beyond classical immune cells such as antigen-presenting cells (APCs) and NK cells to include non-immune populations like stromal, epithelial, and even malignant cells

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