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As a RhoGEF, ARHGEF3 exhibits a distinct cellular spatial distribution, primarily localized to the cell membrane and nucleus (Singh et al, 2021)

10.1016/j.stem.2010.11.028 62 LeemanD

21 (4), e70103

These quinolines are characterized by a weak basic moiety and a lipophilic chain in the quinoline structure, and the leishmanicidal response has shown a consistent correlation with depolarization of mitochondrial potential, promoting a series of biological and biochemical consequences into the parasite, including an increase of ROS production, alteration of parasite morphology and parasite death via apoptosis (Figure 6)

"Identification, characterization and structure of a new Delta class glutathione transferase isoenzyme"

ROS comprises both free and non-free radicals derived from oxygen atoms, including superoxide anion (O 2 - ), hydrogen peroxide (H 2 O 2 ), hydroxyl radicals (OH ), and singlet oxygen ( 1 O 2 ) [4]