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Interaction of cupric ions (Cu 2+ ) with superoxide radical anion (O 2 - ) or reducing agents like ascorbic acid (AscH - ) or glutathione (GSH) results in the formation of cuprous species Cu + Cuprous ions can catalyze the production of hydroxyl radicals from hydrogen peroxide through the Fenton reaction (Haber-Weiss mechanism) (Bremner, 1993[49]) The hydroxyl radical exhibits a high degree of reactivity, enabling it to interact with nearly all biological molecules in close proximity through the hydrogen abstraction mechanism, which results in the formation of carbon-centered radicals, such as lipid radicals derived from unsaturated fatty acids

Therefore, addition of the reactive aldehydes, to known risks of T2DM and DN, would allow clinicians to both identify patients at risk of progression and monitor therapeutic intervention and patient management

Nutrients 14 , 228 (2022)

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Dietary essential fatty acids and brain function: a developmental perspective on mechanisms