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However, nanoparticles smaller than 5 nm are more easily eliminated by liver filtration[63]

Biochem Biophys Res Commun 209:227233 Mulcahy RT, Untawale S, Gipp JJ (1994) Transcriptional up-regulation of gamma-glutamylcysteine synthetase gene expression in melphalan-resistant human prostate carcinoma cells

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Zitka O, Skalickova S, Gumulec J, Masarik M, Adam V, Hubalek J, Trnkova L, Kruseova J, Eckschlager T, Kizek R

Walcher T, Haenle MM, Mason RA, Koenig W, Imhof A, Kratzer W

It should be noted that although ROS play a central role in regulating oxygen homeostasis [537, 538], it was traditionally considered as harmful byproducts of aerobic metabolism but not key signaling molecules that regulate cellular processes until recent years [538, 539]