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In male reproductive pathology, ROS generated by mitochondria in asthenozoospermic sperm cause nuclear DNA strand breaks [358] and compromise chromatin condensation integrity through aberrant histone methylation patterns, which directly correlates with diminished sperm quality [351]

Cellular responses to oxidative stress: Adaptation, damage, repair, senescence and death

Pyrgiotakis, G

doi: 10.1210/jc.2004-0039 36 SakaiKDErcoleAJMurphyLJClemmonsDR

Proteins are longer chains (hundreds) that serve structural, enzymatic and transport roles