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Notably, ACSL4-deficient MM cells exhibit resistance to RSL3, while ACSL4-high cells are highly sensitive, supporting the rationale for targeting ferroptosis in ACSL4-overexpressing MM subtypes to overcome chemoresistance

More recently, immunoprecipitation-based RT-QUiC, detected pathogenic alpha-synuclein in serum, with high sensitivity and specificity in discriminating PD as well as DLB from controls 105

The lack of long-term biosafety assessments is a major concern, as some nanomaterials may accumulate in vivo , causing chronic toxicity or immune reactions that require long-term monitoring

doi: 10.1002/adhm.202203085 165 WangYLiuTLiXShengHMaXHaoL

Doom JR, Gunnar MR

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