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Thus, CARN depletion may impair active tubular secretion of MTX, leading to decreased clearance and higher serum levels

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Be patient while resuspending the beads in the buffer and try to avoid pumping air into the tube

However, the latest data from the CIRT, with its negative results, imply that the inflammatory pathway is rather complex and that the adenosine-mediated anti-inflammatory effect of methotrexate might not be as effective as canakinumab at targeting IL-1

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