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Nrf2, a transcription factor regulating the expression of antioxidant response elements such as GPX4, exerts its antioxidant effects through nuclear translocation 48

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Importantly, it is reported that women are at a higher risk than men of developing pain-related disorders and increased sensitivity to induced visceral and somatic pain [85]

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Although traditional Chinese medicine research has identified several signaling pathways that regulate ferroptosis, over 90% of these studies are confined to rodent models, without validation of targets or dosage in human patients