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HGF, as a ligand, binds to a receptor tyrosine kinase Met at its extracellular region and activates the kinase activity residing in the cytoplasmic domain

Interestingly, data from the Multi-Ethnic Study of Atherosclerosis (MESA) demonstrated that when LDL-C and LDL-P are discordant (Figure 8), then LDL-P proves to be a better predictor of risk for incident CVD events than LDL-C (475)