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PMID 22169943

Emerging research points to a critical imbalance in the body's ability to manage oxidative stress and clear cellular debris, highlighting the vital role of a molecule known as the "master antioxidant." In the quest to understand and manage these complex chronic conditions, medical science is increasingly focusing on mitochondrial health and systemic detoxification

To circumvent this limitation, transgenic mice models expressing human ACE2 (hACE2) are available, but there are some limitations regarding their use: (1) there are reports that SARS-CoV-2 induces mortality on 7 d postinfection (dpi) limiting their use on long-term experiments

Abstract Glutathione peroxidase 4 (GPx4) behaves as an antioxidant enzyme capable of directly reducing peroxidized phospholipids within cell membranes

Results As compared to the healthy controls, schizophrenia patients had decreased baseline GSSG levels (t = -2.115, p = 0.036) and elevated GSH/GSSG ratios (t = 2.141, p = 0.034)

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