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In several cancer cell lines, including HT1080 and PANC1, the knockdown of NCOA4 prevents erastin-induced ferritin breakdown, iron buildup, and ferroptosis

with both the availability of nutrients and the underlying cell phenotype strongly influencing engagement of specific metabolic pathways

[DOI] [PMC free article] [PubMed] [Google Scholar] 400.Cui, X

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To explore whether varying the prime and boost dose affects the immunogenicity of LION/repRNA gH/gL, we evaluated two de-escalating dose regimens, 10 g/1 g and 10 g/0.1 g, and one escalating dose 0.1 g/10 g regimen

Our results indicate that MeCbl may bind to GSDME and thereby inhibit its activity via adopting base-off conformation in coordination to the Cys residue of GSDME