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Smoking kills roughly 443,000 Americans each year and smoking and exposure to secondhand smoke is the leading cause of preventable death and disease in the U.S

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Figure 2 As for the age-standardized mortality rate (ASMR) of laryngeal cancer, both China and the United States have shown a significant downward trend over the past 30 years

In summary, several biomarkers provide an accurate assessment of exposure to toxic chemicals in cigarette smoke

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