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10.1111/febs.15481 19

CSF oligomeric alpha-synuclein and oligomeric/total alpha-synuclein ratio, for example is increased in PD and associated with worsening motor signs, in particular in postural-instability PD subtypes 206 although specificity remains low 205

These are primarily genetic if you have them, your children have an extremely high chance of inheriting them and theyre caused by mutated genes that affect communication between nerve cells

The conserved residue Tyr9 is positioned within hydrogen-bonding distance of the thiolate group of GSH, and this residue has been shown to be important for the catalytic activity of the enzyme 19