glutathione reducing agent mechanism - an overview Glutathione System from Cyanobacteria to

The selective elimination of mtROS reduced the induction of M2 macrophages in HIF1 transgenic mice, and further investigation suggested that mtROS-induced M2 macrophage polarization is mediated through NF-B activation

Kipp AP, Frombach J, Deubel S, Brigelius-Flohe R

The oxidized GSSG can be converted back to GSH through the action of glutathione reductase

IAV infection can induce MAPK phosphatase-5 expression, which has been shown to inhibit IRF3 activation and type I IFN response, thereby enhancing viral replication 77

For example, inhibitors of TMA-lyase (the microbial enzyme turning choline into TMA) have been developed (e.g

doi: 10.1182/blood.2022018303