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1 Introduction Lifetime history of schizophrenia spectrum disorders, including schizophrenia and schizoaffective and schizophreniform disorders, within the US is estimated at 1.8% ( A systematic review and meta-analysis examining the global prevalence of metabolic syndrome in patients with schizophrenia found a pooled prevalence of 41.3%, with significant variability across regions, ranging from 79.1% in France to 18.03% in China ( Metabolic syndrome and antipsychotic-induced weight gain negatively impact quality of life and are common reasons for medication non-adherence and premature discontinuation, creating barriers to symptom remission among people with schizophrenia ( People with schizophrenia and comorbid metabolic syndrome have poorer cognitive performance, possibly resulting in worse symptom remission ( Immune dysregulation and chronic inflammation have been hypothesized as potential risk factors for both metabolic syndrome and the development and worsening of symptoms in individuals with schizophrenia

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More prescribers are willing to prescribe it

However, there are still aspects concerning NR as a biomarker for endocrine disruption that remains to be clarified

Validation: MG, FM, AB, AO