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The acyl-coenzyme A (CoA) synthetase long-chain family (ACSL) located on the mitochondrial outer membrane and endoplasmic reticulum (ER) can catalyze the transformation of fatty acids to acyl-CoAs ( Studies conducted on the haploid cell line KBM7 through insertional mutagenesis indicate that the inactivation of LPCAT3 and ACSL4 allows cells to become resilient against RSL3 and ML162, two GPX4 inhibitors ( - ) and GPX4 are effective suppressors of ferroptosis, while ACSL4 and LPCAT3 are identified as pro-ferroptosis due to their role in incorporating PUFAs into membrane lipids

(4) Monika Misra (2013) Obesity Pharmacotherapy: Current Perspectives and Future Directions Current Cardiology Reviews, 2013 Feb, Volume 9 (Issue 1), Pages 3354

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This relationship makes NAC fundamental for comprehensive wellness, particularly for combating oxidative stress and supporting the detoxification pathways of the liver and kidneys