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The high dependency of therapy-resistant mesenchymal cancer cells (with high ZEB1 expression) on the lipid peroxidase pathway governed by phospholipid glutathione peroxidase 4 ( GPX4 ) increases their vulnerability to ferroptosis via GPX4 inhibition or GSH depletion with erastin treatment [9]

Palivan CG, Goers R, Najer A, Zhang X, Car A, Meier W

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Darwish G.H., Asselin J., Tran M.V., Gupta R., Kim H., Boudreau D., Algar W.R