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Within this global burden, hypothyroidism, hyperthyroidism, and autoimmune thyroid disease (AITD) affect hundreds of millions of individuals

Lancet 1998, 351 (9107) : 9404

Tortuous, immature and unevenly perfused vessels create spatial heterogeneity in vascular access, oxygenation, acidity and drug distribution [11, 12, 15, 68]