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Higher levels of pro-inflammatory bacteria like Flavonifractor and lower levels of Christensenellaceae have been associated with oxidative stress, low-grade inflammation, and more severe symptoms in individuals with BD

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Mitochondrial ROS metabolism is achieved predominantly through the activity of two complementary, yet distinct, thiol-based antioxidant systems 33

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The most prevalent ROS reported to affect lipids profoundly include HO and hydroperoxyl (HO 2 )