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This step is an addition to the PRISMA guideline according to the approach of Mak & Thomas [12]

Clinical data show that higher plasma TMAO is associated with increased risk of major adverse cardiovascular events (MACE) and mortality (Guasti et al., 2021)

Autoimmun Rev (2016) 15:11258

Zhelev Z, Aoki I, Lazarova D, Vlaykova T, Higashi T, Bakalova R (2022) A weird mitochondrial fatty acid oxidation as a metabolic secret of cancer