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In HCC, a dynamic interplay exists between tumor cell metabolic reprogramming and the enrichment and functional enhancement of Tregs [125,126]

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The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice

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Table 5 systematically compares key characteristics of MEVs with other widely studied extracellular vesiclesmesenchymal stem cell-derived EVs and cancer-derived EVshighlighting critical challenges in scalability, stability, targeting capability, and ethical considerations for clinical translation