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It has been demonstrated that at least 10 bacteria per microcolony on endothelial cells are needed to induce the recruitment of ezrin and the consequent cytoskeletal remodeling leading to the internalization of the bacteria (Soyer et al., 2014)

(2023) 19:e059828

Accessed 21 Dec 2010 Astrazeneca LP (2005) EMLA package insert

Preprint at bioRxiv (2020)

In macrophages exposed to conidia, mitophagy is activated to remove ROS-damaged mitochondria and prevent excessive inflammasome activation ( Cryptococcus neoformans infection induces excessive mitophagy, blunting immune cell activation and cytokine production ( 4.5 Fungal-induced mitochondrial signaling and innate immune activation Mitochondria serve as signaling platforms for innate immune pathways such as MAVS-dependent antiviral signaling, the NLRP3 inflammasome, and cGAS-STING

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