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Therefore, Zheng et al

Mitochondrial dna depletion, oxidative stress, and mutation: mechanisms of dysfunction from nucleoside reverse transcriptase inhibitors

It plays a critical role in the regulation of cell building, movement, and differentiation

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For example, in a study by Vandeputte et al., the absolute quantity of microbes (measured using quantitative microbiome profiling) was preferred and utilized over the classic relative abundance profiling, since the latter cannot provide information about the extent of directionality of changes in taxa abundance or metabolic potential [270, 271]