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In addition, these keto-enol tautomers also exist in several cis and trans forms whereby their relative concentrations vary according to temperature, polarity of solvent, pH and substitution of the aromatic rings [56-58]

Despite advances in surgical and pharmacological interventions, the persistence of such symptoms diminishes quality of life and daily functioning of patients (Finnerup et al., 2015

A sour or off odor is a general sign of formulation breakdown