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204 The non-canonical NF-B pathway is crucial in lymphoid organ development, lymphocyte survival and homeostasis, dendritic cell activation, osteoclastogenesis, etc., and its aberrant activation may lead to rheumatoid arthritis, ulcerative colitis, osteoporosis, and lymphoid malignancies

Many people with a B12 deficiency also have a lower than normal bone density

10.1016/j.freeradbiomed.2019.02.019 10

Activation of the p53/p21 pathway can enable cancer cells to resist oxidative stress, and this effect may involve inhibition of nucleotide synthesis (Maddocks et al, 2013)

Renal cell carcinoma in children and young adults: A clinicopathological and immunohistochemical study of 14 cases

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