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These reactions are primarily mediated by UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs), which generate major circulating metabolites such as luteolin-7-O-glucuronide and luteolin-3-O-glucuronide ( in-vivo concentrations may fall below thresholds required to reproduce potent mechanistic effects demonstrated in vitro

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This trial was the first to evaluate the use of oral N-acetylcysteine in monotherapy, associated with broad-spectrum sunscreen, for the treatment of melasma

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these include inhibition of activation of the PI3K/Akt-mediated Nuclear Factor kappa-B (NF-B) and MAPK signaling pathways, as well as the promotion of regulatory T cell (Treg) function and enhancement of alveolar epithelial sodium channel (ENaC) activity (alleviating inflammation and oxidative stress responses)