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Recent experimental evidence suggests that impaired cortical neurogenesis with excess folic acid is similar to that of folate or vitamin B12 deficiency and greatest when folate excess is present with vitamin B12 deficiency

The PBPK model can forecast the effects of perpetrator compounds on drug-metabolizing enzymes and transporters, enabling the prediction of potential clinical DDIs

Dieni S, Matsumoto T, Dekkers M, Rauskolb S, Ionescu MS, Deogracias R, Gundelfinger ED, Kojima M et al (2012) BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons

Progressive multifocal leukoencephalopathy (PML), a rare and serious brain infection, has not been reported in MS patients using Kesimpta, but has developed in other patients given ofatumumab

Prog Nutr 23:e2021241

This modification is thought to improve stability and cellular uptake, with the acetyl group being removed once inside cells to release active glutathione