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37 Furthermore, even if CRF application protects against gastric ulcers, 38 exogenous administration of CRF can reproduce cardinal features of diarrhea predominant irritable bowel syndrome including anxiogenic behavior, enhanced visceral pain to colorectal distention, increased colonic mucus secretion, propulsive motility, development of watery stool/diarrhea, and increased colonic mucosal permeability facilitating bacterial translocation into colonic tissue

Novo is in a head-to-head battle with Eli Lilly to reclaim the obesity market

Food and Drug Administration (FDA) (Press release)

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However, cell-permeable peptides made of D-amino acids are emerging peptidomimetics with promising pharmaceutical applications