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In particular, ZAG decreases fatty acid synthase (FAS), acetyl-coenzyme A carboxylase 1 (ACC1), acyl-coenzyme A: diacylglycerol transferase 1 (DGAT1), and increases hormone-sensitive lipase (HSL) activity, resulting in increased lipolysis and decreased lipogenesis in murine adipose tissue [89]

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the invention also provides a pharmaceutical composition a pharmaceutical composition comprising an effective amount of at least one compound of Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier

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