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TMAO activates vascular smooth muscle cell and endothelial cell MAPK, nuclear factor-B (NF-B) signaling, leading to inflammatory gene expression and endothelial cell adhesion of leukocytes (Seldin et al., 2016)

In summary, the present findings demonstrated that an elevated plasma L-Cn might precipitate the persistence of HBV infection by exerting an immunosuppressive function, indicating a beneficial effect of low L-Cn level in chronic HBV infection

Vet Immunol Immunopathol

Sleep 30 , 12741281 (2007)

We generated an NCI-H446 xenograft mouse model to confirm these changes in vivo , and the results also showed altered levels of IL-6 and IL-1 (Fig