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doi:10.1111/ijcp.14852

Endocrinology 138: 12041214, 1997 [DOI] [PubMed] [Google Scholar] 255.Trajkovic M, Visser TJ, Mittag J, Horn S, Lukas J, Darras VM, Raivich G, Bauer K, Heuer H

Some research suggests that it may also increase your risk of cardiovascular (heart) disease

it is activated by rising levels of ROS and/or its substrate, i.e., GSSG

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Calabrese and Blain, The stress challenges that trigger hormesis include exposure to pollutants, toxins, natural products, caloric restriction, ischemic pre-conditioning, ionizing radiation, and many other stimuli (Schmitt et al., 2002