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GI symptoms, including excessive salivation, dysphagia, constipation, esophageal motility disorders, and gastric abnormalities, occur many years before the appearance of motor symptoms and may be associated with an increased risk of developing PD [112]

Conversely, other studies revealed that the decreased survival of cancer patients is associated with the suppressed expression of GPx2, confirming the tumor-suppressive function of GPx2 (Ren et al