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View Abstract Differentiating between methicillin-resistant and methicillin-sensitive Staphylococcus aureus osteomyelitis in children: an evidence-based clinical prediction algorithm

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doi: 10.1073/pnas.2513640122 Mondal, Victor, Ross-Munro, Emily, Firipis, Kate, Balasuriya, Gayathri K., Kumari, Ritu, Hossen, Md

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Notably, disheveled (Dsh or Dvl) proteins often promote the dephosphorylation of -catenin, thereby interfering with its degradation mainly because activated Dsh proteins drive the separation of GSK-3 from the degradation complex, thereby promoting Wnt/-catenin signaling and targeting the elevation of downstream gene expression

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However, given the proper circumstances and enough time, a protein that has unfolded under sufficiently gentle conditions can refold and may again exhibit biological activity (Figure 2.5.1)

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