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Symptoms of B12 deficiency may include: Depression Fatigue Trouble concentrating Confusion Memory problems Headaches Mood changes Vitamin B12 is essential for red blood cell production, so long-term deficiency can lead to anemia, which can cause fatigue, shortness of breath, and an irregular heartbeat

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Highly variable Northern Hemisphere temperatures reconstructed from low- and high-resolution proxy data

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The titration schedule, the target doses, the injection frequency, all of these remain the same