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Environmental triggers induce mucosal stress, leading to protein citrullination, antigen presentation by dendritic cells, and subsequent autoimmune activation

When the gut barrier breaks down, the brain barrier can follow suit and vice versa

Lewin E, Garfia B, Almaden Y, Rodriguez M, Olgaard K

lucidum ) [17, 18]

However, these thresholds are derived from heterogeneous observational studies that are often not adjusted for metabolic comorbidities or genetic polymorphisms affecting ethanol metabolism [123]

As a potent antioxidant, it inhibits lipid peroxidation and reduces the conversion of arachidonic acid to PGE2, a pro-inflammatory mediator