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These extensive viral protein interactions with host-specific cellular targets could trigger severe human metabolic reprogramming/dysregulation (HMRD), a rewiring of sugar-, amino acid-, lipid-, and nucleotide-metabolism(s), as well as altered or impaired bioenergetics, immune dysfunction, and redox imbalance in the body

As a result of the effects of reactive oxygen and nitrogen species on these structures, modifications occur in the structure and function of various proteins

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Chang, C.-H., et al

Biochemistry 51, 68046815

Gut Microbiota in Human Metabolic Health and Disease