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CBD can also indirectly influence cellular activity by altering the release of neurotransmitters or cytokines from neighbouring cells, leading to non-cell autonomous effects

& Hatanaka, H

Meanwhile, toxicity studies have suggested that paeoniflorin has low acute toxicity, minimal subacute and chronic toxicity, and no genotoxic or mutational toxic effects

As oligodendrocytes are the main sites of iron storage in the brain 24 , the stimulation of FPN1-mediated iron export via decreased hepcidin is expected to increase free extracellular iron, which may, in turn, result in oxidative stress in the SN in PD patients

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and finally employs an endosomal enzyme, cathepsin L (CTSL) for fusogenic release of its viral genome