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Some abnormal plasma elevations of hemostatic parameters, including factor VIII (Freyburger et al, 1997), von Willebrand factor (van den Berg et al, 1995), fibrinogen (von Eckardstein et al, 1994), thrombomodulin (van den Berg et al, 1995), thrombin/antithrombin III complex and activated protein C (Cattaneo, 1999

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This presents a meaningful clinical concern, particularly in populations exposed to polypharmacy or managing complex comorbidities

and most mineral micro (heavy metals) and organic (pesticides, phenols, hydrocarbons, detergents, algal toxins) pollution