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10.1016/j.ibneur.2023.11.002 100 Mar-BausetS.Llopis-GonzlezA.Zazpe-GarcaI.Mar-SanchisA.Morales-Surez-VarelaM

For severe darkening or when home treatments aren't effective, professional options exist

This event is followed by the generation of ROS from the oxidation of FADH2 as induced by the demethylase, with consequent oxidation of nearby guanines (8-oxo-Gs) and recruitment of DNA repair enzymes (among which is APE1) that cause single-strand breaks in DNA and enable looping between the enhencer/promoter and the polyadenylation sites of the target genes, with productive transcription 140,141

PLGA with a copolymer ratio 50:50 (Mw = 50 kDa) and PCL (Mw = 70 kDa) were purchased from Esun Industrial Company, China

The advantages of these therapeutic agents are to strengthen the efficacy of the treatment while reducing the adverse effects usually associated to conventional/systemic chemotherapy as well as to allow the release of the payload from targeted to adjacent cells, thus increasing the overall anti-tumour effect [reviewed in 8 ]

Recent studies have assessed the role of ferroptosis in SCI [8]