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[24] [25] It's important to note that while both medications can affect lipid parameters, large clinical trials (AIM-HIGH and HPS2-THRIVE) have not demonstrated cardiovascular outcome benefits from adding niacin to statin therapy

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Curcumins upregulation of BECN1 and downregulation of P62 and caspase-1 suggests its protective effect via modulation of AMPK-mTOR and NF-B pathways 47,48,49

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