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E.LiH.et al

Nrf2 is a master transcription factor regulating the expression of key enzymes for GSH synthesis (e.g., GCLM, GCLC) and the cystine transporter xCT (SLC7A11) (81)

E.ChunS

Due to UV exposure and melanin synthesis, the melanocytic lineage seems to have a higher rate of ROS (reactive oxygen species) formation

Food Funct (2019) 10:893902

Endogenous sources include various cellular organelles such as mitochondria, peroxisomes, and endoplasmic reticulum, where oxygen consumption rates are elevated