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Simultaneously, it upregulated 10 caspase genes (which eliminate damaged cells) and activated 84 DNA repair genes suggesting a powerful cell-protective function

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Enantiomers were separated and according to computational modeling the inhibitory capacity of the compounds were attributed to the S -configuration of the spiro-oxindole dihydroquinazolinones

Hepatology 63 , 11901204 (2016)

For example, in cultured endothelial cells, lipoic acid was found to inhibit IKK-, an enzyme that promotes the translocation of redox-sensitive and pro-inflammatory transcription factor, nuclear factor-kappa B (NFB) from the cytosol to the nucleus (46)