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Creatine supplementation causes intracellular water retention in muscle tissue, which accounts for initial weight gain of 2-4 pounds

Dalal H, Jolly K, Davis R, Doherty P, Austin J

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Notably, a number of pharmacological and genetic studies demonstrates the existence of a functional crosstalk between NF-B and Nrf2, with a range of cell-type- and tissue-dependent molecular interactions, fundamental for well-coordinated responses in inflammatory processes 88

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Protective effect of cilostazol against doxorubicin-induced cardiomyopathy in mice