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Vojdani A, Mumper E, Granpeesheh D, Mielke L, Traver D, Bock K et al

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Although the evidence specifically for the therapeutic use of sufentanil in neonates shows no clear neurodevelopmental harm, emerging observational data on postnatal opioid exposure in infants undergoing cardiac surgery suggest associations with worse neurodevelopmental outcomes across cognitive, language, and motor domains at 2 years, though these associations are likely confounded by underlying cardiac disease severity and surgical complexity (102, 107)