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cyano-B12 decreased the frequency of recurrent aphthous ulcers in patients with normal (defined as a B12 status of 140 ng/l) as well as with low levels of B12 at baseline

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J Exp Ther Oncol 4:239246 Maher JM, Slitt AL, Cherrington NJ, Cheng X, Klaassen CD (2005) Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice

It irreversibly binds the glutathione in a 1:1 ratio, decreasing its production and favoring its excretion through urine as glutathione-DMF adducts (65)

These modifications fundamentally alter the peptide's pharmacological properties

362,374,375 FZB: FZBs MOA is similar to that of GZB