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[DOI] [PMC free article] [PubMed] [Google Scholar] Hozo 2005 Hozo SP, Djulbegovic B, Hozo I

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if a patient is on blood pressure-lowering drugs (such as beta blockers, alpha-1 blockers, or vasodilators), niacinamide injections could lead to an additive drop in blood pressure

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[1] [2] The vitamin's water-soluble nature means that excess amounts are typically excreted through urine rather than accumulating in the body to toxic levels