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Adaptive immune resistance at the tumour site: mechanisms and therapeutic opportunities

Oxcarbazine (and, more specifically, its active metabolite MHD): Primary mechanism: blocks voltage-sensitive sodium channels, inhibiting repetitive neuronal firing

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van Gent, D

A potential benefit of L-carnitine in these patients is based on the fact that it can (i) increase the oxidation of long-chain fatty acids which accumulation may contribute to insulin resistance in skeletal muscle, and (ii) enhance glucose utilization by reducing acyl-CoA concentration within the mitochondrial matrix (see Biological Activities) (42)

Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest