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To assess the metabolic changes induced by bTNF- in bFLS, we performed a metabolic flux analysis by using d-glucose- 13 C 6 , which generates citrate containing two heavy-labeled carbons (M + 2-labeled citrate) following oxidative decarboxylation of glucose-derived pyruvate

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Although CPT-Axle1 and CPT-Axle3 exhibited comparable cytotoxicity, CPT-ROT1 showed an IC 50 value approximately three times that of CPT-Axle1 , whereas the IC 50 of CPT-ROT3 is 17 times that of CPT-Axle3